Kuo-Hsuan Chang Selected Research

indole

11/2023	Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity.
1/2023	Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson's Disease.
1/2019	Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models.
1/2019	Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer's Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement.
10/2014	The potential of indole and a synthetic derivative for polyQ aggregation reduction by enhancement of the chaperone and autophagy systems.

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Kuo-Hsuan Chang Research Topics

Disease

25	Parkinson Disease (Parkinson's Disease) 01/2024 - 02/2004
19	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 07/2009
14	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2024 - 01/2013
11	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 02/2024 - 01/2013
10	Neuroinflammatory Diseases 02/2024 - 01/2018
9	Huntington Disease (Huntington's Disease) 07/2023 - 01/2012
6	Inflammation (Inflammations) 11/2023 - 01/2018
6	Disease Progression 07/2023 - 01/2019
6	Stroke (Strokes) 01/2020 - 01/2010
5	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 11/2022 - 05/2007
5	Multiple Sclerosis 10/2020 - 07/2009
4	Neuromyelitis Optica (Devic's Disease) 05/2024 - 02/2013
4	Dementia (Dementias) 01/2022 - 08/2018
4	Guillain-Barre Syndrome 01/2018 - 05/2007
3	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 02/2024 - 01/2013
3	Polyneuropathies (Polyneuropathy) 12/2023 - 01/2018
3	Cognitive Dysfunction 04/2023 - 01/2022
3	Neuroblastoma 01/2023 - 01/2021
3	Atrial Fibrillation 01/2022 - 01/2020
3	Hemorrhage 01/2022 - 01/2020
3	Atrophy 07/2016 - 08/2013
2	Anemia 07/2023 - 09/2006
2	Neoplasms (Cancer) 12/2022 - 01/2021
2	Tauopathies 10/2022 - 01/2016
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 06/2014
2	Cerebral Hemorrhage 01/2022 - 01/2015
2	Ischemic Stroke 01/2020 - 01/2018
2	Amyloid Plaque 12/2018 - 02/2016
2	Miller Fisher Syndrome (Fisher Syndrome) 10/2016 - 07/2009
2	Diplopia (Double Vision) 01/2014 - 07/2013
2	Viral Meningitis 07/2009 - 05/2007
1	Demyelinating Diseases (Demyelinating Disease) 05/2024
1	Gaucher Disease (Gaucher's Disease) 01/2024
1	Type 2 Diabetes Mellitus (MODY) 12/2023
1	Hypoalbuminemia 07/2023
1	Thymus Neoplasms (Thymus Neoplasm) 07/2023
1	Infections 07/2023
1	Hypokalemia 07/2023
1	Venous Thrombosis (Deep-Vein Thrombosis) 07/2023
1	Lymphatic Metastasis 12/2022
1	Neoplasm Metastasis (Metastasis) 12/2022

Drug/Important Bio-Agent (IBA)

15	polyglutamineIBA 02/2024 - 01/2012
13	Proteins (Proteins, Gene)FDA Link 02/2024 - 01/2012
13	Biomarkers (Surrogate Marker)IBA 12/2023 - 02/2015
8	SynucleinsIBA 01/2024 - 03/2016
8	Amyloid (Amyloid Fibrils)IBA 01/2022 - 02/2016
5	indoleIBA 11/2023 - 10/2014
5	Brain-Derived Neurotrophic Factor (BDNF)IBA 05/2023 - 06/2007
5	EnzymesIBA 01/2017 - 05/2007
4	Interleukin-6 (Interleukin 6)IBA 02/2024 - 10/2016
4	Phosphotransferases (Kinase)IBA 01/2023 - 01/2013
4	tau Proteins (tau Protein)IBA 01/2021 - 01/2016
4	TATA-Box Binding Protein (TATA-Binding Protein)IBA 01/2020 - 01/2014
4	tributyl phosphate (TBP)IBA 01/2020 - 01/2014
3	Therapeutic UsesIBA 02/2024 - 12/2021
3	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2024 - 01/2019
3	NC009-1 compoundIBA 11/2023 - 01/2019
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2022 - 04/2007
3	AnticoagulantsIBA 01/2022 - 01/2020
3	glycyrrhizae radix et rhizomaIBA 01/2021 - 01/2018
3	ImmunosorbentsIBA 02/2013 - 05/2007
2	Glucosylceramidase (Glucocerebrosidase)IBA 01/2024 - 09/2007
2	Chalcone (Benzalacetophenone)IBA 11/2023 - 01/2021
2	coumarinIBA 11/2023 - 01/2021
2	Anti-Bacterial Agents (Antibiotics)IBA 07/2023 - 09/2006
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2023 - 01/2020
2	LipidsIBA 01/2023 - 01/2017
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2023 - 11/2021
2	Carrier Proteins (Binding Protein)IBA 01/2023 - 10/2022
2	Antidepressive Agents (Antidepressants)IBA 01/2022 - 09/2005
2	N(4)-oleylcytosine arabinosideIBA 01/2022 - 01/2020
2	Vitamin K FDA Link 01/2022 - 01/2020
2	Leucine (L-Leucine)FDA Link 01/2021 - 01/2013
2	AntioxidantsIBA 11/2020 - 10/2018
2	MelibioseIBA 01/2020 - 01/2020
2	HLA-DR Antigens (HLA-DR)IBA 01/2020 - 01/2020
2	Topiramate (Topamax)FDA LinkGeneric 01/2020 - 10/2015
2	Anticonvulsants (Antiepileptic Drugs)IBA 01/2020 - 09/2005
2	Lactulose (Duphalac)FDA LinkGeneric 01/2020 - 01/2020
2	CytokinesIBA 01/2019 - 01/2018
2	Huntingtin ProteinIBA 11/2017 - 01/2016
2	Prealbumin (Transthyretin)IBA 01/2017 - 07/2009
2	GlucocorticoidsIBA 01/2014 - 07/2013
2	HaptoglobinsIBA 02/2013 - 05/2007
1	AutoantibodiesIBA 05/2024
1	ElectrolytesIBA 07/2023
1	AntibodiesIBA 07/2023
1	GangliosidesIBA 07/2023
1	NucleotidesIBA 07/2023
1	Polysaccharides (Glycans)IBA 07/2023
1	NeurotoxinsIBA 01/2023
1	1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)IBA 01/2023
1	ApolipoproteinsIBA 01/2023
1	Glycogen Synthase (Synthase I)IBA 01/2023
1	Lipoproteins (Lipoprotein)IBA 01/2023
1	Thyroglobulin FDA Link 12/2022
1	IodineIBA 12/2022

Therapy/Procedure

8	Therapeutics 10/2022 - 09/2006
2	Plasmapheresis 07/2023 - 03/2020
1	Lymph Node Excision (Lymph Node Dissection) 12/2022